It lies between the Rwenzori Mountains and the regions leading south toward Bwindi and the Virunga landscapes.
The park can be reached by road from Kampala or Entebbe, although many travelers arrive from Kibale National Park as part of a longer western Uganda safari.
Because the protected area is large and includes several distinct sectors, visitors should understand that accommodation location can significantly influence driving times.
A lodge near one activity area may be far from another.
Travelers can reach the park by road from Kampala or Entebbe.
However, many safari itineraries connect Queen Elizabeth with Kibale National Park to the north.
The journey can then continue south toward Bwindi.
Domestic flights may also be incorporated into selected itineraries, although road transfers remain necessary between airstrips, lodges and activity areas.